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Texas Department of Criminal Justice spokesman Jason Clark said that the state's supply of pentobarbital would end in September.
Texas has the highest execution rate in the country, with 11 inmates put to death so far in 2013.
Some drugs companies have objected to their products being used for capital punishment.
Texas has used pentobarbital, a drug used to treat severe epilepsy, in executions since July 2012.
The state was forced to change to the single-dose sedative when supplies of sodium thiopental, one of three drugs used previously, were cut off.
But state officials are now having difficulties with the availability of pentobarbital, which is also typically used to put down animals.
"We will be unable to use our current supply of pentobarbital after it expires,'' the Associated Press news agency quoted department spokesman Jason Clark as saying. "We are exploring all options at this time."
The state is planning at least five more executions this year.
Richard Dieter, who heads the Washington-based Death Penalty Information Center, said other states would be having similar problems.
"The states really scramble to go all over to get drugs,'' he told AP.
"Some went overseas, some got from each other. But these manufacturers - a number them are based in Europe - don't want to participate in our executions. So they've clamped down as much as they can."
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Volumes of research have suggested the death penalty is significantly more expensive to taxpayers than the punishment of life in prison, due largely to the lengthy legal processes involved. Therefore, isn't it more cost effective to let them rot behind bars?